目的 制备自溶性透明质酸微针,为微针经皮给药提供载体,为载药微针的制备奠定基础。方法 以不同相对分子质量透明质酸为原料,根据物料溶解性能,结合溶液流动性、成针平整性、微针形态及机械强度,以微针形态完好、阵列平整稳定、机械强度佳、自溶性能优越、制备成本低廉、使用方便为指标,反复筛选优化工艺。结果 采用平均相对分子质量为1 000~10 000的透明质酸,配置原液浓度为20 mg·mL-1,30 ℃真空(-0.07 MPa)负压注模,常温干燥约24 h,自然脱模,制得光滑平整、机械性能良好的透明质酸微针。结论 该工艺制备流程简便、原料易得、产品稳定、是制备自溶性透明质酸微针的良好方法;透明质酸微针的制备为透明质酸在美容行业的应用提供了新途径,也为后期载药微针及其他药物经皮给药剂型的开发奠定了基础。
Abstract
OBJECTIVE To prepare self-dissolving hyaluronic acid microneedles provide a carrier for transdermal delivery of microneedles and lay a foundation for the preparation of drug-carrying microneedles. METHODS With different molecular weight hyaluronic acid as raw material, according to the solubility of the material, combined with solution fluidity, needle-forming smoothness, microneedle shape state and mechanical strength, the microneedle in good shape, flat and stable array, with good mechanical strength, superior autolysis performance, and low preparation cost with convenience as the index, the process was peatedly screened and optimized. RESULTS Hyaluronic acid with an average molecular weight of 1 000-10 000 was used to prepare a solution with a concentration of 20 mg·mL-1. The pressure was set at -0.07 MPa, the temperature was set at 30 ℃, and the drying time was controlled for about 24 h. The needles were poured to make smooth and smooth hyaluronic acid microneedle with good mechanical properties. CONCLUSION The preparation process is simple, the raw material is easy to get, the product is stable, safe and effective, and it is a good method for the preparation of autolytic hyaluronic acid microneedles. It provides experimental and theoretical basis for the application of microneedle in the new form of medical beauty and skin care, the new way of targeted drug delivery, and the new method of clinical disease drug delivery.
关键词
自溶性 /
透明质酸微针 /
性能表征
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Key words
self-dissolving /
hyaluronic acid microneedle /
performance characterization
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中图分类号：
R944
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参考文献
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脚注
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基金
南京医科大学康达学院科研发展基金重点项目资助(KD2018KYJJZD001);南京医科大学康达学院教研项目资助(KD2018JYYJYB008)
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